Oncology Frontier: Abstract Richter syndrome (RS) or Richter transformation is the development of secondary aggressive. What progress has been made in understanding the genetic events which relate to progression of CLL or transformation into RS?

　　《肿瘤瞭望》：Richter综合征或者Richter转变是在慢性淋巴细胞白血病/小淋巴细胞淋巴瘤的背景中，继发的侵袭性淋巴瘤。对该转变的基因改变研究有无最新进展？

　　Dr Jones: In general， the mechanism by which CLL transforms to high-grade lymphoma， Richter transformation， is not clear. The specific mechanism has not been elucidated. But who are the patients who are at greatest risk? This is the same group of patients who are at higher risk of relapsed and refractory CLL. We know there is an association between IGH mutation status and cytogenetics particularly with deletion 17p， so these patients are over-represented in the group that develop Richter transformation.

　　Jones教授：总体来说，CLL转化成高级别的淋巴瘤、Richter转化的机制并不清楚。IGH突变、del（17p）的患者是上述转化的高危人群。